Surface-modified bioactive glass particles as microcarriers in a microgravity environment

Paul Ducheyne, T. Livingston, I. Shapiro, P. Ayyaswamy, H. Gao, S. Radin

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The development of bone tissue in vitro as a potential bone graft material is discussed. By growing bone cells on a bioactive substrate, in vitro synthesis of bone tissue can be achieved. Since dedifferentiation of osteoprogenitor cells can easily occur in in vitro systems, we focus on a template material that stimulates the expression of the osteoblast phenotype. While gradually resorbing, surface-modified bioactive glass promotes the expression of the osteoblastic phenotype and acts as a template for deposition of bone tissue. For this template to be clinically successful, it is necessary to promote rapid and abundant bone tissue formation in vitro. This paper reviews the criteria for the selection of the synthetic template material, discusses its effect on cell function, and addresses the issue of optimizing culture conditions by using a microgravity environment. The adaptation of the surface-treated glass particles to serve as a substrate in microgravity conditions is also presented.

Original languageEnglish (US)
Pages (from-to)219-229
Number of pages11
JournalTissue Engineering
Issue number3
StatePublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biotechnology
  • Cell Biology


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