Synthesis and characterization of new fluorene-based singlet oxygen sensitizers

Kevin D. Belfield, Claudia C. Corredor, Alma R. Morales, Marie A. Dessources, Florencio E. Hernandez

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The synthesis, photophysical characterization, and determination of singlet oxygen quantum yields (Φ Δ) for a class of fluorene derivatives with potential application in two-photon photodynamic therapy (PDT) is reported. It has been demonstrated that these compounds possess the ability to generate singlet oxygen ( 1O 2) upon excitation. A photochemical method, using 1,3-diphenylisobenzofuran (DPBF) as 1O 2 chemical quencher, was employed to determine the singlet oxygen quantum yields (Φ Δ) of the fluorene-based photosensitizers in ethanol. Φ Δ values ranged from 0.35 to 0.75. These derivatives may have potential application as two-photon photosensitizers when pumped via two-photon excitation in the near-IR spectral region.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalJournal of Fluorescence
Volume16
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Psychology
  • Social Sciences (miscellaneous)
  • Sociology and Political Science
  • Spectroscopy
  • Clinical Biochemistry
  • Law

Keywords

  • Photodynamic therapy
  • Photosensitizer
  • Singlet oxygen
  • Two-photon absorption

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