Synthesis and characterization of new fluorene-based singlet oxygen sensitizers

Kevin D. Belfield; Claudia C. Corredor; Alma R. Morales; Marie A. Dessources; Florencio E. Hernandez

doi:10.1007/s10895-005-0008-1

Synthesis and characterization of new fluorene-based singlet oxygen sensitizers

Kevin D. Belfield
, Claudia C. Corredor
, Alma R. Morales
, Marie A. Dessources
, Florencio E. Hernandez

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The synthesis, photophysical characterization, and determination of singlet oxygen quantum yields (Φ _Δ) for a class of fluorene derivatives with potential application in two-photon photodynamic therapy (PDT) is reported. It has been demonstrated that these compounds possess the ability to generate singlet oxygen ( ¹O ₂) upon excitation. A photochemical method, using 1,3-diphenylisobenzofuran (DPBF) as ¹O ₂ chemical quencher, was employed to determine the singlet oxygen quantum yields (Φ _Δ) of the fluorene-based photosensitizers in ethanol. Φ _Δ values ranged from 0.35 to 0.75. These derivatives may have potential application as two-photon photosensitizers when pumped via two-photon excitation in the near-IR spectral region.

Original language	English (US)
Pages (from-to)	105-110
Number of pages	6
Journal	Journal of Fluorescence
Volume	16
Issue number	1
DOIs	https://doi.org/10.1007/s10895-005-0008-1
State	Published - Jan 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Psychology
Social Sciences (miscellaneous)
Sociology and Political Science
Spectroscopy
Clinical Biochemistry
Law

Keywords

Photodynamic therapy
Photosensitizer
Singlet oxygen
Two-photon absorption

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10.1007/s10895-005-0008-1

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title = "Synthesis and characterization of new fluorene-based singlet oxygen sensitizers",

abstract = "The synthesis, photophysical characterization, and determination of singlet oxygen quantum yields (Φ Δ) for a class of fluorene derivatives with potential application in two-photon photodynamic therapy (PDT) is reported. It has been demonstrated that these compounds possess the ability to generate singlet oxygen ( 1O 2) upon excitation. A photochemical method, using 1,3-diphenylisobenzofuran (DPBF) as 1O 2 chemical quencher, was employed to determine the singlet oxygen quantum yields (Φ Δ) of the fluorene-based photosensitizers in ethanol. Φ Δ values ranged from 0.35 to 0.75. These derivatives may have potential application as two-photon photosensitizers when pumped via two-photon excitation in the near-IR spectral region.",

keywords = "Photodynamic therapy, Photosensitizer, Singlet oxygen, Two-photon absorption",

author = "Belfield, \{Kevin D.\} and Corredor, \{Claudia C.\} and Morales, \{Alma R.\} and Dessources, \{Marie A.\} and Hernandez, \{Florencio E.\}",

note = "Funding Information: The authors acknowledge the Research Corporation, the donors of the Petroleum Research Fund of the American Chemical Society, and the Florida Hospital Gala Endowed Award for Oncologic Research for support. Dr. Mykhailo V. Bondar and Mr. Erwan Baleine are gratefully acknowledged for helpful discussions. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2006",

month = jan,

doi = "10.1007/s10895-005-0008-1",

language = "English (US)",

volume = "16",

pages = "105--110",

journal = "Journal of Fluorescence",

issn = "1053-0509",

publisher = "Springer",

number = "1",

}

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T1 - Synthesis and characterization of new fluorene-based singlet oxygen sensitizers

AU - Belfield, Kevin D.

AU - Corredor, Claudia C.

AU - Morales, Alma R.

AU - Dessources, Marie A.

AU - Hernandez, Florencio E.

N1 - Funding Information: The authors acknowledge the Research Corporation, the donors of the Petroleum Research Fund of the American Chemical Society, and the Florida Hospital Gala Endowed Award for Oncologic Research for support. Dr. Mykhailo V. Bondar and Mr. Erwan Baleine are gratefully acknowledged for helpful discussions. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2006/1

Y1 - 2006/1

N2 - The synthesis, photophysical characterization, and determination of singlet oxygen quantum yields (Φ Δ) for a class of fluorene derivatives with potential application in two-photon photodynamic therapy (PDT) is reported. It has been demonstrated that these compounds possess the ability to generate singlet oxygen ( 1O 2) upon excitation. A photochemical method, using 1,3-diphenylisobenzofuran (DPBF) as 1O 2 chemical quencher, was employed to determine the singlet oxygen quantum yields (Φ Δ) of the fluorene-based photosensitizers in ethanol. Φ Δ values ranged from 0.35 to 0.75. These derivatives may have potential application as two-photon photosensitizers when pumped via two-photon excitation in the near-IR spectral region.

AB - The synthesis, photophysical characterization, and determination of singlet oxygen quantum yields (Φ Δ) for a class of fluorene derivatives with potential application in two-photon photodynamic therapy (PDT) is reported. It has been demonstrated that these compounds possess the ability to generate singlet oxygen ( 1O 2) upon excitation. A photochemical method, using 1,3-diphenylisobenzofuran (DPBF) as 1O 2 chemical quencher, was employed to determine the singlet oxygen quantum yields (Φ Δ) of the fluorene-based photosensitizers in ethanol. Φ Δ values ranged from 0.35 to 0.75. These derivatives may have potential application as two-photon photosensitizers when pumped via two-photon excitation in the near-IR spectral region.

KW - Photodynamic therapy

KW - Photosensitizer

KW - Singlet oxygen

KW - Two-photon absorption

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U2 - 10.1007/s10895-005-0008-1

DO - 10.1007/s10895-005-0008-1

M3 - Article

C2 - 16365698

AN - SCOPUS:33645667859

SN - 1053-0509

VL - 16

SP - 105

EP - 110

JO - Journal of Fluorescence

JF - Journal of Fluorescence

IS - 1

ER -

Synthesis and characterization of new fluorene-based singlet oxygen sensitizers

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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