TY - JOUR
T1 - Synthesis and immobilization of micro-scale drug particles in cellulosic films
AU - Meng, Xiangxin
AU - Yang, Dachuan
AU - Keyvan, Golshid
AU - Michniak-Kohn, Bozena
AU - Mitra, Somenath
N1 - Funding Information:
The authors wish to acknowledge financial support from National Science Foundation grants , the Center for Structured Organic Composites for Pharmaceutical, Nutraceutical, and Agrochemical Applications ( NSF ERC: EEC-0540855 ), NanoPharmaceutical Engineering and Science ( NSF IGERT: DGE-0504497 ) and Computation and Communication: Promoting Research Integration in Science and Mathematics ( NSF C 2 PRISM: DGE-0638423 ). The authors also like to thank Dr. Rajesh Dave for his help and assistance at various levels.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50. min.
AB - The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50. min.
KW - Anti-solvent
KW - Drug delivery
KW - Griseofulvin
KW - Hydrophobic drugs
KW - Oral dosage form
KW - Polymer film
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U2 - 10.1016/j.colsurfb.2011.03.040
DO - 10.1016/j.colsurfb.2011.03.040
M3 - Article
C2 - 21524894
AN - SCOPUS:79955804709
SN - 0927-7765
VL - 86
SP - 181
EP - 188
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 1
ER -