Synthesis and immobilization of micro-scale drug particles in cellulosic films

Xiangxin Meng; Dachuan Yang; Golshid Keyvan; Bozena Michniak-Kohn; Somenath Mitra

doi:10.1016/j.colsurfb.2011.03.040

Synthesis and immobilization of micro-scale drug particles in cellulosic films

Xiangxin Meng, Dachuan Yang, Golshid Keyvan, Bozena Michniak-Kohn, Somenath Mitra

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50. min.

Original language	English (US)
Pages (from-to)	181-188
Number of pages	8
Journal	Colloids and Surfaces B: Biointerfaces
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2011.03.040
State	Published - Aug 1 2011

All Science Journal Classification (ASJC) codes

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

Keywords

Anti-solvent
Drug delivery
Griseofulvin
Hydrophobic drugs
Oral dosage form
Polymer film

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10.1016/j.colsurfb.2011.03.040

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title = "Synthesis and immobilization of micro-scale drug particles in cellulosic films",

abstract = "The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50. min.",

keywords = "Anti-solvent, Drug delivery, Griseofulvin, Hydrophobic drugs, Oral dosage form, Polymer film",

author = "Xiangxin Meng and Dachuan Yang and Golshid Keyvan and Bozena Michniak-Kohn and Somenath Mitra",

note = "Funding Information: The authors wish to acknowledge financial support from National Science Foundation grants , the Center for Structured Organic Composites for Pharmaceutical, Nutraceutical, and Agrochemical Applications ( NSF ERC: EEC-0540855 ), NanoPharmaceutical Engineering and Science ( NSF IGERT: DGE-0504497 ) and Computation and Communication: Promoting Research Integration in Science and Mathematics ( NSF C 2 PRISM: DGE-0638423 ). The authors also like to thank Dr. Rajesh Dave for his help and assistance at various levels.",

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doi = "10.1016/j.colsurfb.2011.03.040",

language = "English (US)",

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AU - Meng, Xiangxin

AU - Yang, Dachuan

AU - Keyvan, Golshid

AU - Michniak-Kohn, Bozena

AU - Mitra, Somenath

N1 - Funding Information: The authors wish to acknowledge financial support from National Science Foundation grants , the Center for Structured Organic Composites for Pharmaceutical, Nutraceutical, and Agrochemical Applications ( NSF ERC: EEC-0540855 ), NanoPharmaceutical Engineering and Science ( NSF IGERT: DGE-0504497 ) and Computation and Communication: Promoting Research Integration in Science and Mathematics ( NSF C 2 PRISM: DGE-0638423 ). The authors also like to thank Dr. Rajesh Dave for his help and assistance at various levels.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50. min.

AB - The anti-solvent synthesis of micron-scale particles, their stabilization, and subsequent self-assembly into polymer films suitable for drug delivery is presented. The colloidal particles were stabilized using low molecular weight hydroxypropyl methylcellulose (HPMC), while drug encapsulation was carried out with high molecular weight HPMC and polyvinylpyrrolidone (PVP). Griseofulvin (GF) was used as the model drug compound, and the polymer films were evaluated in terms of their surface morphology, mechanical properties and in vitro drug release. In general, the release rates were best described by first-order and Hixson-Crowell kinetic models, and in a typical film containing 57% HPMC, 100% of GF was released within 50. min.

KW - Anti-solvent

KW - Drug delivery

KW - Griseofulvin

KW - Hydrophobic drugs

KW - Oral dosage form

KW - Polymer film

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Synthesis and immobilization of micro-scale drug particles in cellulosic films

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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