Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

Xiangxin Meng, Dachuan Yang, Golshid Keyvan, Bozena Michniak-Kohn, Somenath Mitra

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalColloids and Surfaces B: Biointerfaces
Volume92
DOIs
StatePublished - Apr 1 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Keywords

  • Anti-solvent
  • Cyclodextrin
  • Drug delivery
  • Griseofulvin
  • Hydrophobic drugs
  • Polymer film

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