Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

Xiangxin Meng; Dachuan Yang; Golshid Keyvan; Bozena Michniak-Kohn; Somenath Mitra

doi:10.1016/j.colsurfb.2011.11.043

Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

Xiangxin Meng, Dachuan Yang, Golshid Keyvan, Bozena Michniak-Kohn, Somenath Mitra

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.

Original language	English (US)
Pages (from-to)	213-222
Number of pages	10
Journal	Colloids and Surfaces B: Biointerfaces
Volume	92
DOIs	https://doi.org/10.1016/j.colsurfb.2011.11.043
State	Published - Apr 1 2012

All Science Journal Classification (ASJC) codes

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

Keywords

Anti-solvent
Cyclodextrin
Drug delivery
Griseofulvin
Hydrophobic drugs
Polymer film

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10.1016/j.colsurfb.2011.11.043

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title = "Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins",

abstract = "The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.",

keywords = "Anti-solvent, Cyclodextrin, Drug delivery, Griseofulvin, Hydrophobic drugs, Polymer film",

author = "Xiangxin Meng and Dachuan Yang and Golshid Keyvan and Bozena Michniak-Kohn and Somenath Mitra",

note = "Funding Information: The authors wish to acknowledge financial support from National Science Foundation grants, the Center for Structured Organic Composites for Pharmaceutical, Nutraceutical, and Agrochemical applications ( NSF ERC: EEC-0540855 ), NanoPharmaceutical Engineering and Science ( NSF IGERT: DGE-0504497 ) and Computation and Communication: Promoting Research Integration in Science and Mathematics ( NSF C 2 PRISM: DGE-0638423 ). The authors also like to thank Dr. Rajesh Dave for his help and assistance at various levels.",

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doi = "10.1016/j.colsurfb.2011.11.043",

language = "English (US)",

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AU - Meng, Xiangxin

AU - Yang, Dachuan

AU - Keyvan, Golshid

AU - Michniak-Kohn, Bozena

AU - Mitra, Somenath

N1 - Funding Information: The authors wish to acknowledge financial support from National Science Foundation grants, the Center for Structured Organic Composites for Pharmaceutical, Nutraceutical, and Agrochemical applications ( NSF ERC: EEC-0540855 ), NanoPharmaceutical Engineering and Science ( NSF IGERT: DGE-0504497 ) and Computation and Communication: Promoting Research Integration in Science and Mathematics ( NSF C 2 PRISM: DGE-0638423 ). The authors also like to thank Dr. Rajesh Dave for his help and assistance at various levels.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.

AB - The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.

KW - Anti-solvent

KW - Cyclodextrin

KW - Drug delivery

KW - Griseofulvin

KW - Hydrophobic drugs

KW - Polymer film

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ER -

Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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