A practical method for radiofluorination of anilines with [18F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18F-labeling to prepare [18F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18F-labeled neuropeptide.
All Science Journal Classification (ASJC) codes
- click chemistry
- peptide radiolabeling