Synthesis of [18F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones

Maruthi Kumar Narayanam, Gaoyuan Ma, Pier Alexandre Champagne, Kendall N. Houk, Jennifer M. Murphy

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A practical method for radiofluorination of anilines with [18F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18F-labeling to prepare [18F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18F-labeled neuropeptide.

Original languageEnglish (US)
Pages (from-to)13006-13010
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number42
DOIs
StatePublished - Oct 9 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • click chemistry
  • fluorine-18
  • fluoroarene
  • peptide radiolabeling
  • sydnone

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