Abstract
Mechanisms that lead to traumatic brain injury due to blast exposure (bTBI) are not well understood. Complexities of cellular responses involved have made identification of these mechanisms challenging. In-vitro studies of blast induced traumatic brain injury are possible with employment of shock tubes which closely mimic the loading conditions of blasts in a laboratory setting. A novel pneumatic, two-chamber shock tube has been developed to generate a span of mild to severe pressure waveforms seen in TBI literature [1-2]. Unlike other shock tubes utilized in TBI research, it is small, portable, controllable and most importantly safe to operate. The ultimate goal is to use this device to develop a blast induced traumatic brain injury animal model that can be used to explain the injury mechanism(s) and threshold levels of brain injury after blast exposure.
Original language | English (US) |
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Title of host publication | 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 |
Pages | 51-52 |
Number of pages | 2 |
DOIs | |
State | Published - Jun 29 2012 |
Event | 38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States Duration: Mar 16 2012 → Mar 18 2012 |
Other
Other | 38th Annual Northeast Bioengineering Conference, NEBEC 2012 |
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Country/Territory | United States |
City | Philadelphia, PA |
Period | 3/16/12 → 3/18/12 |
All Science Journal Classification (ASJC) codes
- Bioengineering