Target discovery of ebselen with a biotinylated probe

Zhenzhen Chen, Zhongyao Jiang, Nan Chen, Qian Shi, Lili Tong, Fanpeng Kong, Xiufen Cheng, Hao Chen, Chu Wang, Bo Tang

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Despite numerous studies on ebselen over the past decade, its cellular targets remain obscure. Here we synthesized a biotinylated ebselen probe (biotin-ebselen) and characterized ebselen-binding proteins via an efficient activity-based protein profiling (ABPP) method, which allowed for the robust identification of 462 targeted proteins in HeLa cells. This first work of global target profiling of ebselen will be helpful to re-design ebselen-based therapy appropriately in clinical trials.

Original languageEnglish (US)
Pages (from-to)9506-9509
Number of pages4
JournalChemical Communications
Issue number68
StatePublished - 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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