TCP performance over wireless networks is critical as the Internet gradually expands to the wireless territory. Traditional TCP schemes have been proven to be inefficient for the wireless network, as they are designed and optimized for the wired network. Recently, schemes that are aimed to improve TCP performance in wireless networks have been proposed. In particular, TCP-Jersey, a TCP scheme that was designed for heterogeneous network consisting of wired and wireless links, has shown significant improvement over other TCP variants. In this paper, performance of TCP-Jersey over High Speed Downlink Packet Access (HSDPA) in the Universal Mobile Telecommunication System (UMTS) is evaluated and compared with other TCP variants through detailed system modeling and extensive simulations. The result shows that TCP-Jersey produces significant goodput improvement over other TCP variants tested.