Temporal dynamics of spontaneous default-mode network activity mediate the association between reappraisal and depression

Wei Gao, Sheng Dong Chen, Bharat Biswal, Xu Lei, Jia Jin Yuan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Cognitive reappraisal is associated with major depressive disorder (MDD), while spontaneous activity patterns of the default mode network (DMN) is implicated in reappraisal and MDD. However, neural mechanisms subserving the close association of spontaneous reappraisal and depression are unclear. Spontaneous reappraisal, depression and resting-state functional magnetic resonance imaging (rsfMRI) were measured from 105 healthy subjects. We assessed the temporal complexity (Hurst exponent), Regional Homogeneity (ReHo) and fractional Amplitude of Low Frequency Fluctuation (fALFF) profiles of DMN, a network involved in both reappraisal and depression. Mediation effects of these standard measures on the relationship between reappraisal and depression, and the contributions of each DMN subregion, were assessed. Results indicated that Hurst exponent (H) of DMN, whether extracted by independent component analysis (ICA) or region of interest (ROI), was significantly associated with reappraisal scores. An individual with a higher reappraisal score has a lower Hurst value of DMN. Mediation analyses suggest that H of DMN partially mediates the association between reappraisal and the degree of depression, and this mediation effect arises from the contribution of medial prefrontal cortex. Neither ReHo nor fALFF showed a similar correlation or mediation effect. These findings suggest that temporal dynamics of DMN play an important role in emotion regulation and its association with depression. H of DMN may serve as a neural marker mediating the association between reappraisal and depression.

Original languageEnglish (US)
Pages (from-to)1235-1247
Number of pages13
JournalSocial cognitive and affective neuroscience
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2018

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Keywords

  • Hurst
  • default mode network
  • depression
  • emotion regulation
  • reappraisal

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