Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder

Shugao Xia; Xiaobo Li; Ariane E. Kimball; Mary S. Kelly; Iris Lesser; Craig Branch

doi:10.1016/j.pscychresns.2012.04.011

Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder

Shugao Xia, Xiaobo Li, Ariane E. Kimball, Mary S. Kelly, Iris Lesser, Craig Branch

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.

Original language	English (US)
Pages (from-to)	161-167
Number of pages	7
Journal	Psychiatry Research - Neuroimaging
Volume	204
Issue number	2-3
DOIs	https://doi.org/10.1016/j.pscychresns.2012.04.011
State	Published - Nov 30 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

Keywords

ADHD
DTI tractography
Magnetic resonance imaging (MRI)
Shape analysis
Thalamus

Access to Document

10.1016/j.pscychresns.2012.04.011

Cite this

@article{39863d8c3333451da0641c510e61d485,

title = "Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder",

abstract = "Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.",

keywords = "ADHD, DTI tractography, Magnetic resonance imaging (MRI), Shape analysis, Thalamus",

author = "Shugao Xia and Xiaobo Li and Kimball, {Ariane E.} and Kelly, {Mary S.} and Iris Lesser and Craig Branch",

note = "Funding Information: This work was partially supported by a Rose F. Kennedy IDD Research Center program grant ( HD071593 ) from the National Institutes of Health, and was conducted at and sponsored by the Gruss Magnetic Resonance Research Center of the Albert Einstein College of Medicine. The authors would also like to present their gratitude to Mr. Sada Guzman and Ms. Yrany Alvarado for their contributions to the MR data acquisition.",

year = "2012",

month = nov,

day = "30",

doi = "10.1016/j.pscychresns.2012.04.011",

language = "English (US)",

volume = "204",

pages = "161--167",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder

AU - Xia, Shugao

AU - Li, Xiaobo

AU - Kimball, Ariane E.

AU - Kelly, Mary S.

AU - Lesser, Iris

AU - Branch, Craig

N1 - Funding Information: This work was partially supported by a Rose F. Kennedy IDD Research Center program grant ( HD071593 ) from the National Institutes of Health, and was conducted at and sponsored by the Gruss Magnetic Resonance Research Center of the Albert Einstein College of Medicine. The authors would also like to present their gratitude to Mr. Sada Guzman and Ms. Yrany Alvarado for their contributions to the MR data acquisition.

PY - 2012/11/30

Y1 - 2012/11/30

N2 - Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.

AB - Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.

KW - ADHD

KW - DTI tractography

KW - Magnetic resonance imaging (MRI)

KW - Shape analysis

KW - Thalamus

UR - http://www.scopus.com/inward/record.url?scp=84872391121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872391121&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2012.04.011

DO - 10.1016/j.pscychresns.2012.04.011

M3 - Article

C2 - 23149038

AN - SCOPUS:84872391121

SN - 0925-4927

VL - 204

SP - 161

EP - 167

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

IS - 2-3

ER -

Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this