TY - JOUR
T1 - The Biology of Bone and Ligament Healing
AU - Cottrell, Jessica A.
AU - Turner, Jessica Cardenas
AU - Arinzeh, Treena Livingston
AU - O'Connor, J. Patrick
N1 - Funding Information:
Disclosure Statement: Dr T.L. Arinzeh receives research funding from the Department of Defense (W81XWH-14-1-0482) , National Science Foundation , Musculoskeletal Transplant Foundation (Treena Arinzeh’s grant) , New Jersey Commission on Spinal Cord Research( CSCR16ERG014) , Christopher L. Moseley Foundation , and Integra LifeSciences , Inc. Dr J.P. O’Connor is an owner of Accelalox Inc, which is developing novel therapies to promote bone regeneration, and receives research funding from the Musculoskeletal Transplant Foundation and the National Institutes of Health . Dr J.A. Cottrell have nothing to disclose. Dr J.C. Turner receives research funding from National Aeronautics and Space Administration Fellowship (NNX13AL56H).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - This review describes the normal healing process for bone, ligaments, and tendons, including primary and secondary healing as well as bone-to-bone fusion. It depicts the important mediators and cell types involved in the inflammatory, reparative, and remodeling stages of each healing process. It also describes the main challenges for clinicians when trying to repair bone, ligaments, and tendons with a specific emphasis on Charcot neuropathy, fifth metatarsal fractures, arthrodesis, and tendon sheath and adhesions. Current treatment options and research areas are also reviewed.
AB - This review describes the normal healing process for bone, ligaments, and tendons, including primary and secondary healing as well as bone-to-bone fusion. It depicts the important mediators and cell types involved in the inflammatory, reparative, and remodeling stages of each healing process. It also describes the main challenges for clinicians when trying to repair bone, ligaments, and tendons with a specific emphasis on Charcot neuropathy, fifth metatarsal fractures, arthrodesis, and tendon sheath and adhesions. Current treatment options and research areas are also reviewed.
KW - Arthrodesis
KW - Bone fracture healing
KW - Charcot neuropathy
KW - Fifth metatarsal fractures
KW - Tendon and ligament healing
KW - Tissue regeneration
KW - Wound healing
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U2 - 10.1016/j.fcl.2016.07.017
DO - 10.1016/j.fcl.2016.07.017
M3 - Review article
C2 - 27871408
AN - SCOPUS:84996503818
SN - 1083-7515
VL - 21
SP - 739
EP - 761
JO - Foot and Ankle Clinics
JF - Foot and Ankle Clinics
IS - 4
ER -