The buckling of capillaries in solid tumours

James MacLaurin, Jon Chapman, Gareth Wyn Jones, Tiina Roose

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We develop a model of the buckling (both planar and axial) of capillaries in cancer tumours, using nonlinear solid mechanics. The compressive stress in the tumour interstitium is modelled as a consequence of the rapid proliferation of the tumour cells, using a multiplicative decomposition of the deformation gradient. In turn, the tumour cell proliferation is determined by the oxygen concentration (which is governed by the diffusion equation) and the solid stress. We apply a linear stability analysis to determine the onset of mechanical instability, and the Liapunov-Schmidt reduction to determine the postbuckling behaviour. We find that planar modes usually go unstable before axial modes, so that our model can explain the buckling of capillaries, but not as easily their tortuosity. We also find that the inclusion of anisotropic growth in our model can substantially affect the onset of buckling. Anisotropic growth also results in a feedback effect that substantially affects the magnitude of the buckle.

Original languageEnglish (US)
Pages (from-to)4123-4145
Number of pages23
JournalProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume468
Issue number2148
DOIs
StatePublished - Dec 8 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Mathematics(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Keywords

  • Buckle
  • Cancer
  • Capillary
  • Nonlinear elasticity

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