The characterization of biodegradable polymers with different process histories

Research output: Contribution to conferencePaperpeer-review

Abstract

Understanding the characteristics of biomaterialsthat have been processed for fabricating implantable devices is of great importance. The order of the material and the processing history may play a role in how cellular attachment proteins adsorb and subsequently, how cells attach and form tissue. This study investigates the behavior of three biopolymers - poly(I)-lactic acid, 12,10 polyarylate, and 2,4 polyarylate - processed into four variants - undrawn, drawn, annealed at constant length, and annealed but free-to-shrink. Using DSC, we analyzed the spectra of the materials, relating peaks to changes in molecular structure. We also simulated the in vivo environment using a 37°C water bath, measuring the response of materials as a change In length. From the DSC spectra, poly(l)-lactic acid contained a well defined glass transition, crystallization, and melting region, 12,10 polyarylate was drastically affected by the processing conditions in the number and temperatures at which conversion took place, and 2,4 polyarylate remained relatively benign to processing conditions except at conversion temperatures. This analysis correlated the molecular configuration of the biopolymers to the behavior under different processing and environmental conditions. The influence of intrinsic properties of each variant on cellular proliferation will be the focus of future study.

Original languageEnglish (US)
Pages201-202
Number of pages2
StatePublished - Aug 22 2003
EventProceedings of the IEEE 29th Annual Northeast Bioengineering Conference - Newark, NJ, United States
Duration: Mar 22 2003Mar 23 2003

Other

OtherProceedings of the IEEE 29th Annual Northeast Bioengineering Conference
CountryUnited States
CityNewark, NJ
Period3/22/033/23/03

All Science Journal Classification (ASJC) codes

  • Bioengineering

Keywords

  • Biopolymers
  • Material processing
  • Poly(I)-lactic acid
  • Polyarylate

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