The choice of a performance indicator of release in transdermal drug delivery systems

Giuseppe Pontrelli, Laurent Simon

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

An effective time constant for first-order processes is defined to capture the dynamics of systems represented by partial differential equations. In this chapter, the methodology is applied to passive and electrically assisted drug controlled transdermal delivery devices in two case studies. The analysis, which is carried out using Laplace-transformed variables, results in a first-order approximation and does not require time-domain solutions. Numerical experiments are included to illustrate the effectiveness of the index under different conditions and to estimate the time it takes to establish a steady-state flux across the membrane.

Original languageEnglish (US)
Title of host publicationLecture Notes in Applied and Computational Mechanics
PublisherSpringer Verlag
Pages49-64
Number of pages16
DOIs
StatePublished - Jan 1 2018

Publication series

NameLecture Notes in Applied and Computational Mechanics
Volume84
ISSN (Print)1613-7736

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Computational Theory and Mathematics

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