TY - JOUR
T1 - The impact of environmental chemicals on the gut microbiome
AU - Chiu, Karen
AU - Warner, Genoa
AU - Nowak, Romana A.
AU - Flaws, Jodi A.
AU - Mei, Wenyan
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Since the surge of microbiome research in the last decade, many studies have provided insight into the causes and consequences of changes in the gut microbiota. Among the multiple factors involved in regulating the microbiome, exogenous factors such as diet and environmental chemicals have been shown to alter the gut microbiome significantly. Although diet substantially contributes to changes in the gut microbiome, environmental chemicals are major contaminants in our food and are often overlooked. Herein, we summarize the current knowledge on major classes of environmental chemicals (bisphenols, phthalates, persistent organic pollutants, heavy metals, and pesticides) and their impact on the gut microbiome, which includes alterations in microbial composition, gene expression, function, and health effects in the host. We then discuss health-related implications of gut microbial changes, which include changes in metabolism, immunity, and neurological function.
AB - Since the surge of microbiome research in the last decade, many studies have provided insight into the causes and consequences of changes in the gut microbiota. Among the multiple factors involved in regulating the microbiome, exogenous factors such as diet and environmental chemicals have been shown to alter the gut microbiome significantly. Although diet substantially contributes to changes in the gut microbiome, environmental chemicals are major contaminants in our food and are often overlooked. Herein, we summarize the current knowledge on major classes of environmental chemicals (bisphenols, phthalates, persistent organic pollutants, heavy metals, and pesticides) and their impact on the gut microbiome, which includes alterations in microbial composition, gene expression, function, and health effects in the host. We then discuss health-related implications of gut microbial changes, which include changes in metabolism, immunity, and neurological function.
KW - Environmental chemicals
KW - Gut microbiome
KW - Health risks
UR - http://www.scopus.com/inward/record.url?scp=85087281777&partnerID=8YFLogxK
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U2 - 10.1093/toxsci/kfaa065
DO - 10.1093/toxsci/kfaa065
M3 - Review article
C2 - 32392306
AN - SCOPUS:85087281777
SN - 1096-6080
VL - 176
SP - 253
EP - 284
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 2
ER -