The interaction between facilitation and depression of two release mechanisms in a single synapse

Lian Zhou; Robert LoMauro; Farzan Nadim

doi:10.1016/j.neucom.2005.12.032

The interaction between facilitation and depression of two release mechanisms in a single synapse

Lian Zhou, Robert LoMauro, Farzan Nadim

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The synapse from the lateral pyloric (LP) to the pyloric dilator (PD) neuron in the stomatogastric nervous system of the crab Cancer borealis has both a graded and a spike-mediated component. These two components have opposite short-term dynamics: the spike-mediated component is usually facilitating, while the graded component is depressing. We built a model of these two synaptic components and their interactions, based on the concept of quantal release evoked by calcium influx. This model is able to accurately predict the postsynaptic response of the PD neuron to any temporally patterned presynaptic LP neuron activity.

Original language	English (US)
Pages (from-to)	1001-1005
Number of pages	5
Journal	Neurocomputing
Volume	69
Issue number	10-12
DOIs	https://doi.org/10.1016/j.neucom.2005.12.032
State	Published - May 2006

All Science Journal Classification (ASJC) codes

Computer Science Applications
Cognitive Neuroscience
Artificial Intelligence

Keywords

Central pattern generator
Graded release
Short-term plasticity
Spike-mediated release
Stomatogastric

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10.1016/j.neucom.2005.12.032

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title = "The interaction between facilitation and depression of two release mechanisms in a single synapse",

abstract = "The synapse from the lateral pyloric (LP) to the pyloric dilator (PD) neuron in the stomatogastric nervous system of the crab Cancer borealis has both a graded and a spike-mediated component. These two components have opposite short-term dynamics: the spike-mediated component is usually facilitating, while the graded component is depressing. We built a model of these two synaptic components and their interactions, based on the concept of quantal release evoked by calcium influx. This model is able to accurately predict the postsynaptic response of the PD neuron to any temporally patterned presynaptic LP neuron activity.",

keywords = "Central pattern generator, Graded release, Short-term plasticity, Spike-mediated release, Stomatogastric",

author = "Lian Zhou and Robert LoMauro and Farzan Nadim",

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T1 - The interaction between facilitation and depression of two release mechanisms in a single synapse

AU - Zhou, Lian

AU - LoMauro, Robert

AU - Nadim, Farzan

N1 - Funding Information: Supported by NIH MH-60605 (FN).

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AB - The synapse from the lateral pyloric (LP) to the pyloric dilator (PD) neuron in the stomatogastric nervous system of the crab Cancer borealis has both a graded and a spike-mediated component. These two components have opposite short-term dynamics: the spike-mediated component is usually facilitating, while the graded component is depressing. We built a model of these two synaptic components and their interactions, based on the concept of quantal release evoked by calcium influx. This model is able to accurately predict the postsynaptic response of the PD neuron to any temporally patterned presynaptic LP neuron activity.

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KW - Short-term plasticity

KW - Spike-mediated release

KW - Stomatogastric

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JO - Neurocomputing

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The interaction between facilitation and depression of two release mechanisms in a single synapse

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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