The interaction between facilitation and depression of two release mechanisms in a single synapse

Lian Zhou, Robert LoMauro, Farzan Nadim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The synapse from the lateral pyloric (LP) to the pyloric dilator (PD) neuron in the stomatogastric nervous system of the crab Cancer borealis has both a graded and a spike-mediated component. These two components have opposite short-term dynamics: the spike-mediated component is usually facilitating, while the graded component is depressing. We built a model of these two synaptic components and their interactions, based on the concept of quantal release evoked by calcium influx. This model is able to accurately predict the postsynaptic response of the PD neuron to any temporally patterned presynaptic LP neuron activity.

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalNeurocomputing
Volume69
Issue number10-12
DOIs
StatePublished - May 2006

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence

Keywords

  • Central pattern generator
  • Graded release
  • Short-term plasticity
  • Spike-mediated release
  • Stomatogastric

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