The ovarian cancer oncobiome

Sagarika Banerjee, Tian Tian, Zhi Wei, Natalie Shih, Michael D. Feldman, James C. Alwine, George Coukos, Erle S. Robertson

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Humans and other mammals are colonized by microbial agents across the kingdom which can represent a unique microbiome pattern. Dysbiosis of the microbiome has been associated with pathology including cancer. We have identified a microbiome signature unique to ovarian cancers, one of the most lethal malignancies of the female reproductive system, primarily because of its asymptomatic nature during the early stages in development. We screened ovarian cancer samples along with matched, and non-matched control samples using our pan-pathogen array (PathoChip), combined with capture-next generation sequencing. The results show a distinct group of viral, bacterial, fungal and parasitic signatures of high significance in ovarian cases. Further analysis shows specific viral integration sites within the host genome of tumor samples, which may contribute to the carcinogenic process. The ovarian cancer microbiome signature provides insights for the development of targeted therapeutics against ovarian cancers.

Original languageEnglish (US)
Pages (from-to)36225-36245
Number of pages21
JournalOncotarget
Volume8
Issue number22
DOIs
StatePublished - May 30 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology

Keywords

  • microbiome
  • next generation sequencing
  • oncobiome
  • ovarian cancer
  • pathochip

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