The Role of Oral Steroids in the Treatment of Phonotraumatic Vocal Fold Lesions in Women

Milan R. Amin, Stratos Achlatis, Shirley Gherson, Yixin Fang, Binhuan Wang, Hayley Born, Ryan C. Branski, Aaron M. Johnson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives: (1) To determine the short-term effectiveness of oral steroids in women with benign vocal fold lesions and (2) to determine the effectiveness of adjuvant oral steroids in women undergoing voice therapy for benign vocal fold lesions. Study Design: Randomized, double-blind, placebo-controlled clinical trial. Setting: Tertiary voice care center. Subjects and Methods: Thirty-six patients undergoing voice therapy for the treatment of phonotraumatic vocal fold lesions randomly received either a 4-day course of oral steroids or a placebo prior to initiating voice therapy. Voice Handicap Index–10 (VHI-10) scores, video and audioperceptual analyses, acoustic and aerodynamic analyses at baseline, and patient perception of improvement after a short course of steroids or a placebo and at the conclusion of voice therapy were collected. Results: Thirty patients completed the study, of whom 27 (only female) were analyzed. The primary outcome measure, VHI-10, did not improve after the 4-day course of steroids or placebo. Secondary measures similarly showed no improvement with steroids relative to placebo. Voice therapy demonstrated a positive effect on both VHI-10 and patient-perceived improvement of voice in all subjects. Conclusion: A short course of oral steroids did not benefit women with phonotraumatic vocal fold lesions. In addition, steroids had little beneficial effect when used adjunctively with voice therapy in this patient cohort.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number3
StatePublished - Mar 1 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology


  • glucocorticoids
  • larynx
  • steroid
  • vocal fold
  • voice
  • voice therapy


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