The study of electrochemistry with ambient mass spectrometry

Pengyuan Liu; Qiuling Zheng; Howard D. Dewald; Rebecca Zhou; Hao Chen

doi:10.1016/j.trac.2015.02.018

The study of electrochemistry with ambient mass spectrometry

Pengyuan Liu, Qiuling Zheng, Howard D. Dewald, Rebecca Zhou, Hao Chen

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Ambient ionization methods, which can be used to ionize samples directly with no or little preparation under ambient conditions, are a new generation of ionization technologies for mass spectrometry (MS). In this article, we review the coupling of electrochemistry (EC) and MS using ambient ionization methods, such as liquid-sample desorption electrospray ionization (DESI), nanospray DESI and flowing atmospheric pressure afterglow (FAPA). With these novel coupling interfaces, unique applications could be realized, such as online reduction and analysis of disulfide bond-containing proteins and peptides, and investigation of electrochemical reactions on electrode surfaces.

Original language	English (US)
Pages (from-to)	20-30
Number of pages	11
Journal	TrAC - Trends in Analytical Chemistry
Volume	70
DOIs	https://doi.org/10.1016/j.trac.2015.02.018
State	Published - Jul 1 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Spectroscopy

Keywords

Ambient ionization
Disulfide proteomics analysis
Electrochemical reaction
Electrochemistry
Electrode surface
Flowing atmospheric pressure afterglow
Liquid-sample desorption electrospray ionization
Mass spectrometry
Nanospray desorption electrospray ionization
Proteomics

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10.1016/j.trac.2015.02.018

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title = "The study of electrochemistry with ambient mass spectrometry",

abstract = "Ambient ionization methods, which can be used to ionize samples directly with no or little preparation under ambient conditions, are a new generation of ionization technologies for mass spectrometry (MS). In this article, we review the coupling of electrochemistry (EC) and MS using ambient ionization methods, such as liquid-sample desorption electrospray ionization (DESI), nanospray DESI and flowing atmospheric pressure afterglow (FAPA). With these novel coupling interfaces, unique applications could be realized, such as online reduction and analysis of disulfide bond-containing proteins and peptides, and investigation of electrochemical reactions on electrode surfaces.",

keywords = "Ambient ionization, Disulfide proteomics analysis, Electrochemical reaction, Electrochemistry, Electrode surface, Flowing atmospheric pressure afterglow, Liquid-sample desorption electrospray ionization, Mass spectrometry, Nanospray desorption electrospray ionization, Proteomics",

author = "Pengyuan Liu and Qiuling Zheng and Dewald, {Howard D.} and Rebecca Zhou and Hao Chen",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

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day = "1",

doi = "10.1016/j.trac.2015.02.018",

language = "English (US)",

volume = "70",

pages = "20--30",

journal = "TrAC - Trends in Analytical Chemistry",

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TY - JOUR

T1 - The study of electrochemistry with ambient mass spectrometry

AU - Liu, Pengyuan

AU - Zheng, Qiuling

AU - Dewald, Howard D.

AU - Zhou, Rebecca

AU - Chen, Hao

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Ambient ionization methods, which can be used to ionize samples directly with no or little preparation under ambient conditions, are a new generation of ionization technologies for mass spectrometry (MS). In this article, we review the coupling of electrochemistry (EC) and MS using ambient ionization methods, such as liquid-sample desorption electrospray ionization (DESI), nanospray DESI and flowing atmospheric pressure afterglow (FAPA). With these novel coupling interfaces, unique applications could be realized, such as online reduction and analysis of disulfide bond-containing proteins and peptides, and investigation of electrochemical reactions on electrode surfaces.

AB - Ambient ionization methods, which can be used to ionize samples directly with no or little preparation under ambient conditions, are a new generation of ionization technologies for mass spectrometry (MS). In this article, we review the coupling of electrochemistry (EC) and MS using ambient ionization methods, such as liquid-sample desorption electrospray ionization (DESI), nanospray DESI and flowing atmospheric pressure afterglow (FAPA). With these novel coupling interfaces, unique applications could be realized, such as online reduction and analysis of disulfide bond-containing proteins and peptides, and investigation of electrochemical reactions on electrode surfaces.

KW - Ambient ionization

KW - Disulfide proteomics analysis

KW - Electrochemical reaction

KW - Electrochemistry

KW - Electrode surface

KW - Flowing atmospheric pressure afterglow

KW - Liquid-sample desorption electrospray ionization

KW - Mass spectrometry

KW - Nanospray desorption electrospray ionization

KW - Proteomics

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U2 - 10.1016/j.trac.2015.02.018

DO - 10.1016/j.trac.2015.02.018

M3 - Review article

AN - SCOPUS:84937976280

SN - 0165-9936

VL - 70

SP - 20

EP - 30

JO - TrAC - Trends in Analytical Chemistry

JF - TrAC - Trends in Analytical Chemistry

ER -

The study of electrochemistry with ambient mass spectrometry

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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