Abstract
Ambient ionization methods, which can be used to ionize samples directly with no or little preparation under ambient conditions, are a new generation of ionization technologies for mass spectrometry (MS). In this article, we review the coupling of electrochemistry (EC) and MS using ambient ionization methods, such as liquid-sample desorption electrospray ionization (DESI), nanospray DESI and flowing atmospheric pressure afterglow (FAPA). With these novel coupling interfaces, unique applications could be realized, such as online reduction and analysis of disulfide bond-containing proteins and peptides, and investigation of electrochemical reactions on electrode surfaces.
Original language | English (US) |
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Pages (from-to) | 20-30 |
Number of pages | 11 |
Journal | TrAC - Trends in Analytical Chemistry |
Volume | 70 |
DOIs | |
State | Published - Jul 1 2015 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Spectroscopy
Keywords
- Ambient ionization
- Disulfide proteomics analysis
- Electrochemical reaction
- Electrochemistry
- Electrode surface
- Flowing atmospheric pressure afterglow
- Liquid-sample desorption electrospray ionization
- Mass spectrometry
- Nanospray desorption electrospray ionization
- Proteomics