Three-dimensional analyses of a perforated cylindrical drug delivery device

Laurent Simon, Juan Ospina

Research output: Contribution to journalArticlepeer-review

Abstract

A closed-formed solution of a perforated drug-delivery model was developed. Laplace transforms were applied to the governing equation, which included diffusion through the tubular device and mass transfer across a rectangular cut. A first-order estimate for the fraction of drug released, in terms of the Laplace variable, was derived after employing suitable boundary and initial conditions. The effective time constant for the process was calculated. The residue theorem and the Zakian method were proposed as two reliable approaches to recover the solution in the time domain. Simulations show that the drug was released faster at higher Sherwood numbers. Ninety-eight percent (98%) of the loading dose was delivered after a period corresponding to four time constants. This analytical platform can aid in the design of implants for long-term delivery applications.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume481
Issue number1-2
DOIs
StatePublished - Jan 24 2015

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Controlled release
  • Cylindrical device
  • Effective time constant
  • Residue theorem
  • Three-dimensional model

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