Time sequential prediction of ventricular-vascular interactions

T. W. Latson, W. C. Hunter, D. Burkhoff, K. Sagawa

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A new analytical method (sequential convolution) for describing ventricular-vascular interactions was used to predict instantaneous pressure and flow in four isolated canine left ventricles ejecting into a computer-simulated arterial system. Ventricular pumping ability was described by a load-independent elastance, [E*(t)] combined with a ventricular internal resistance. 'Arterial' properties were characterized using a time-based impulse response function that is derived from impedance measurements. Sequential convolution was then used to couple these independent descriptions of ventricular and vascular properties. Predicted pressure-volume trajectories, as well as instaneous pressures and flows, closely matched the experimental data. Stroke volume, peak pressure, and peak flow were typically within 5% of measured values. This method provides a powerful analytical technique for examining ventricular-vascular interactions and has potential application in evaluating the ventricular-loading effects of more complex in vivo vascular properties.

Original languageEnglish (US)
Pages (from-to)H1341-H1353
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6 (20/6)
StatePublished - 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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