TY - JOUR
T1 - Time sequential prediction of ventricular-vascular interactions
AU - Latson, T. W.
AU - Hunter, W. C.
AU - Burkhoff, D.
AU - Sagawa, K.
PY - 1986
Y1 - 1986
N2 - A new analytical method (sequential convolution) for describing ventricular-vascular interactions was used to predict instantaneous pressure and flow in four isolated canine left ventricles ejecting into a computer-simulated arterial system. Ventricular pumping ability was described by a load-independent elastance, [E*(t)] combined with a ventricular internal resistance. 'Arterial' properties were characterized using a time-based impulse response function that is derived from impedance measurements. Sequential convolution was then used to couple these independent descriptions of ventricular and vascular properties. Predicted pressure-volume trajectories, as well as instaneous pressures and flows, closely matched the experimental data. Stroke volume, peak pressure, and peak flow were typically within 5% of measured values. This method provides a powerful analytical technique for examining ventricular-vascular interactions and has potential application in evaluating the ventricular-loading effects of more complex in vivo vascular properties.
AB - A new analytical method (sequential convolution) for describing ventricular-vascular interactions was used to predict instantaneous pressure and flow in four isolated canine left ventricles ejecting into a computer-simulated arterial system. Ventricular pumping ability was described by a load-independent elastance, [E*(t)] combined with a ventricular internal resistance. 'Arterial' properties were characterized using a time-based impulse response function that is derived from impedance measurements. Sequential convolution was then used to couple these independent descriptions of ventricular and vascular properties. Predicted pressure-volume trajectories, as well as instaneous pressures and flows, closely matched the experimental data. Stroke volume, peak pressure, and peak flow were typically within 5% of measured values. This method provides a powerful analytical technique for examining ventricular-vascular interactions and has potential application in evaluating the ventricular-loading effects of more complex in vivo vascular properties.
UR - http://www.scopus.com/inward/record.url?scp=0023036822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023036822&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.1986.251.6.h1341
DO - 10.1152/ajpheart.1986.251.6.h1341
M3 - Article
C2 - 3789185
AN - SCOPUS:0023036822
SN - 0363-6135
VL - 251
SP - H1341-H1353
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 6 (20/6)
ER -