TMS-EEG responses across the lifespan: Measurement, methods for characterisation and identified responses

Elisa Kallioniemi, Jukka Saari, Florinda Ferreri, Sara Määttä

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) allows probing of the neurophysiology of any neocortical brain area in vivo with millisecond accuracy. TMS-EEG is particularly unique compared with other available neurophysiological methods, as it can measure the state and dynamics of excitatory and inhibitory systems separately. Because of these capabilities, TMS-EEG responses are sensitive to the brain state, and the responses are influenced by brain maturation and ageing, making TMS-EEG a suitable method to study age-specific pathophysiology. In this review, we outline the TMS-EEG measurement procedure, the existing methods used for characterising TMS-EEG responses and the challenges associated with identifying the responses. We also summarise the findings thus far on how TMS-EEG responses change across the lifespan and the TMS-EEG features that separate typical and atypical brain maturation and ageing. Finally, we give an overview of the gaps in current knowledge to provide directions for future studies.

Original languageEnglish (US)
Article number109430
JournalJournal of Neuroscience Methods
StatePublished - Jan 15 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


  • Electroencephalography
  • Lifespan
  • TEP
  • TMS-evoked potential
  • Transcranial magnetic stimulation


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