Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies

Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Major depressive disorder (MDD) causes great decrements in health and quality of life with increments in healthcare costs, but the causes and pathogenesis of depression remain largely unknown, which greatly prevent its early detection and effective treatment. With the advancement of neuroimaging approaches, numerous functional and structural alterations in the brain have been detected in MDD and more recently attempts have been made to apply these findings to clinical practice. In this review, we provide an updated summary of the progress in translational application of psychoradiological findings in MDD with a specified focus on potential clinical usage. The foreseeable clinical applications for different MRI modalities were introduced according to their role in disorder classification, subtyping, and prediction. While evidence of cerebral structural and functional changes associated with MDD classification and subtyping was heterogeneous and/or sparse, the ACC and hippocampus have been consistently suggested to be important biomarkers in predicting treatment selection and treatment response. These findings underlined the potential utility of brain biomarkers for clinical practice.

Original languageEnglish (US)
Pages (from-to)528-540
Number of pages13
JournalFrontiers of Medicine
Issue number4
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • General Medicine


  • MRI
  • biomarker
  • major depressive disorder
  • psychoradiology


Dive into the research topics of 'Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies'. Together they form a unique fingerprint.

Cite this