Treatment of Neurogenic Cough with Tramadol: A Pilot Study

Gregory R. Dion, Stephanie E. Teng, Efstratios Achlatis, Yixin Fang, Milan R. Amin

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


This study employs validated cough assessment tools to prospectively determine the impact of tramadol on cough severity and quality of life in subjects with neurogenic cough. The study was a prospective case series with planned data collection at a tertiary care academic medical center laryngology practice. Sixteen consecutive collected subjects with neurogenic cough prospectively completed pre- and posttreatment validated cough assessment tools, the cough severity index (CSI) and Leicester Cough Questionnaire (LCQ). All subjects in the study reported at least some improvement in their cough symptoms. In a Wilcoxon signed rank test that compared paired results, CSI scores improved from 23 to 14 and LCQ scores improved from 74 to 103 (P =.003 and P =.005, respectively). This small preliminary assessment suggests that tramadol warrants additional evaluation as a treatment for neurogenic cough.

Original languageEnglish (US)
Pages (from-to)77-79
Number of pages3
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number1
StatePublished - Jul 1 2017

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology


  • cough
  • neurogenic cough
  • neurogenic cough treatment
  • neuropathic cough treatment
  • tramadol


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