Two-compartment pharmacokinetic models for chemical engineers

Kumud Kanneganti, Laurent Simon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A series of experiments, inspired by two-compartment model, were designed to introduce chemical engineering students to pharmacokinetics and to stimulate their interest in research related to drug delivery and drug pharmacokinetics. According to two-compartment model representation, the human body is comprised of a central compartment consisting of the blood/plasma and well-perfused tissues, and a peripheral compartment mainly composed of poorly perfused tissues. Samples were collected every 15 minutes for both the central and the peripheral compartments and analyzed with a spectrophotometer set at 530 nm. The results show that multiple bolus-injections and constant-rate infusions can be studied after a slight modification of the model and initial conditions. The optimization code, based on a two-compartment model and written in the Mathematica® environment, minimized the sum of squared errors between the concentrations in the central compartment and a desired KMnO4 level of 3.46 g/L for an experimental duration of 5.75 hours.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalChemical Engineering Education
Volume45
Issue number2
StatePublished - Mar 1 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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