Two-dimensional solution and analysis of a cylindrical matrix device with a circular release area

Laurent Simon, Juan Ospina

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A cylindrical device was analyzed using a Laplace transform-based method. The two-dimensional model represented a pharmaceutical agent uniformly distributed in a polymeric matrix surrounded by an impermeable layer. Molecules could be transferred only through a small hole centered at the top surface of the cylinder. A closed-form solution was obtained to help study the effects of design parameters and geometries on the cumulative amount of drug released. The latter variable increased with the mass transfer and diffusion coefficients and decreased with any increment in the device's length. The delivery rate was described by an effective time constant calculated from Laplace transforms. Reducing the orifice diameter or fabricating a longer system would delay transport of the medication. Simplified expressions for the release profile and the time constant were derived for special design cases.

Original languageEnglish (US)
Pages (from-to)115-138
Number of pages24
JournalChemical Engineering Communications
Volume200
Issue number1
DOIs
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Keywords

  • Controlled release
  • Diffusion
  • Drug delivery
  • Effective time constant
  • Mathematical modeling
  • Simulation
  • Transport phenomena

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