@article{a9a105490ed5439ab67d1dc50c0b7654,
title = "Understanding and Interrupting the Fischer Azaindolization Reaction",
abstract = "Experimental and computational studies pertaining to the Fischer azaindolization reaction are reported. These studies explain why pyridylhydrazines are poorly reactive in Fischer indolization reactions, in addition to the origin of hydrazine substituent effects. Additionally, an interrupted variant of Fischer azaindolization methodology is disclosed, which provides a synthetic entryway into fused azaindoline scaffolds.",
author = "Simmons, {Bryan J.} and Marie Hoffmann and Champagne, {Pier Alexandre} and Elias Picazo and Katsuya Yamakawa and Morrill, {Lucas A.} and Houk, {K. N.} and Garg, {Neil K.}",
note = "Funding Information: The authors are grateful to the NSF (CHE-1464898 to N.K.G., CHE-1361104 to K.N.H. and DGE-1144087 for B.J.S.), the Fulbright Research Fellowship (M.H.), the Fonds de recherche du Que{\'b} ec, Nature et Technologies (postdoctoral fellowship for P A.C.), the NIH-NIGMS (F31-GM117945 to E.P. and F31-GM121016 to L.A.M), the Foote Family (E.P. and L.A.M.), and UCLA for financial support. These studies were supported by shared instrumentation grants from the NSF (CHE-1048804) and the NIH NCRR (S10RR025631). Computations were performed on the Hoffman2 cluster at UCLA. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = oct,
day = "25",
doi = "10.1021/jacs.7b07518",
language = "English (US)",
volume = "139",
pages = "14833--14836",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "42",
}