Upconversion nanoparticles: A versatile solution to multiscale biological imaging

Xiang Wu, Guanying Chen, Jie Shen, Zhanjun Li, Yuanwei Zhang, Gang Han

Research output: Contribution to journalReview articlepeer-review

179 Scopus citations


Lanthanide-doped photon upconverting nanomaterials are emerging as a new class of imaging contrast agents, providing numerous unprecedented possibilities in the realm of biomedical imaging. Because of their ability to convert long-wavelength near-infrared excitation radiation into shorter-wavelength emissions, these nanomaterials are able to produce assets of low imaging background, large anti-Stokes shift, as well as high optical penetration depth of light for deep tissue optical imaging or light-activated drug release and therapy. The aim of this review is to line up some issues associated with conventional fluorescent probes, and to address the recent advances of upconverting nanoparticles (UCNPs) as a solution to multiscale biological imaging applications.

Original languageEnglish (US)
Pages (from-to)166-175
Number of pages10
JournalBioconjugate Chemistry
Issue number2
StatePublished - Feb 18 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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