Upconverting NIR photons for bioimaging

Zhanjun Li; Yuanwei Zhang; Hieu La; Richard Zhu; Ghida El-Banna; Yuzou Wei; Gang Han

doi:10.3390/nano5042148

Upconverting NIR photons for bioimaging

Zhanjun Li, Yuanwei Zhang, Hieu La, Richard Zhu, Ghida El-Banna, Yuzou Wei, Gang Han

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Lanthanide-doped upconverting nanoparticles (UCNPs) possess unique anti-Stokes optical properties, in which low energy near-infrared (NIR) photons can be converted into high energy UV, visible, shorter NIR emission via multiphoton upconversion processes. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPs can be fabricated with narrow distribution and tunable multi-color optical properties. These unique attributes grant them unique NIR-driven imaging/drug delivery/therapeutic applications, especially in the cases of deep tissue environments. In this brief review, we introduce both the basic concepts of and recent progress with UCNPs in material engineering and theranostic applications in imaging, molecular delivery, and tumor therapeutics. The aim of this brief review is to address the most typical progress in basic mechanism, material design as bioimaging tools.

Original language	English (US)
Pages (from-to)	2148-2168
Number of pages	21
Journal	Nanomaterials
Volume	5
Issue number	4
DOIs	https://doi.org/10.3390/nano5042148
State	Published - Dec 4 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemical Engineering
General Materials Science

Keywords

Optical imaging
Optical therapy
Upconversion nanoparticles

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10.3390/nano5042148

Cite this

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title = "Upconverting NIR photons for bioimaging",

abstract = "Lanthanide-doped upconverting nanoparticles (UCNPs) possess unique anti-Stokes optical properties, in which low energy near-infrared (NIR) photons can be converted into high energy UV, visible, shorter NIR emission via multiphoton upconversion processes. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPs can be fabricated with narrow distribution and tunable multi-color optical properties. These unique attributes grant them unique NIR-driven imaging/drug delivery/therapeutic applications, especially in the cases of deep tissue environments. In this brief review, we introduce both the basic concepts of and recent progress with UCNPs in material engineering and theranostic applications in imaging, molecular delivery, and tumor therapeutics. The aim of this brief review is to address the most typical progress in basic mechanism, material design as bioimaging tools.",

keywords = "Optical imaging, Optical therapy, Upconversion nanoparticles",

author = "Zhanjun Li and Yuanwei Zhang and Hieu La and Richard Zhu and Ghida El-Banna and Yuzou Wei and Gang Han",

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T1 - Upconverting NIR photons for bioimaging

AU - Li, Zhanjun

AU - Zhang, Yuanwei

AU - La, Hieu

AU - Zhu, Richard

AU - El-Banna, Ghida

AU - Wei, Yuzou

AU - Han, Gang

PY - 2015/12/4

Y1 - 2015/12/4

N2 - Lanthanide-doped upconverting nanoparticles (UCNPs) possess unique anti-Stokes optical properties, in which low energy near-infrared (NIR) photons can be converted into high energy UV, visible, shorter NIR emission via multiphoton upconversion processes. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPs can be fabricated with narrow distribution and tunable multi-color optical properties. These unique attributes grant them unique NIR-driven imaging/drug delivery/therapeutic applications, especially in the cases of deep tissue environments. In this brief review, we introduce both the basic concepts of and recent progress with UCNPs in material engineering and theranostic applications in imaging, molecular delivery, and tumor therapeutics. The aim of this brief review is to address the most typical progress in basic mechanism, material design as bioimaging tools.

AB - Lanthanide-doped upconverting nanoparticles (UCNPs) possess unique anti-Stokes optical properties, in which low energy near-infrared (NIR) photons can be converted into high energy UV, visible, shorter NIR emission via multiphoton upconversion processes. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPs can be fabricated with narrow distribution and tunable multi-color optical properties. These unique attributes grant them unique NIR-driven imaging/drug delivery/therapeutic applications, especially in the cases of deep tissue environments. In this brief review, we introduce both the basic concepts of and recent progress with UCNPs in material engineering and theranostic applications in imaging, molecular delivery, and tumor therapeutics. The aim of this brief review is to address the most typical progress in basic mechanism, material design as bioimaging tools.

KW - Optical imaging

KW - Optical therapy

KW - Upconversion nanoparticles

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DO - 10.3390/nano5042148

M3 - Review article

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VL - 5

SP - 2148

EP - 2168

JO - Nanomaterials

JF - Nanomaterials

IS - 4

ER -

Upconverting NIR photons for bioimaging

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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