Use of fNIRS to assess resting state functional connectivity

Chun Ming Lu, Yu Jin Zhang, Bharat B. Biswal, Yu Feng Zang, Dan Ling Peng, Chao Zhe Zhu

Research output: Contribution to journalArticlepeer-review

234 Scopus citations


Recently, resting state functional connectivity (RSFC) studies based on fMRI and EEG/MEG have provided valuable insight into the intrinsic functional architecture of the human brain. However, whether functional near infrared spectroscopy (fNIRS), a suitable imaging method for infant and patient populations, can be used to examine RSFC remains elusive. Using an ETG-4000 Optical Topography System, the present study measured 29 adult subjects (14 females) over the sensorimotor and auditory cortexes during a resting session and a motor-localizer task session. The RSFC maps were computed by seed-based correlation analysis and data-driven cluster analysis. The results from both analyses showed robust RSFC maps, which were not only consistent with the localizer task-related activation results, but also those of previous fMRI findings. Moreover, the strong consistency between the seed-based correlation analysis and the data-driven cluster analysis further validated the use of fNIRS to assess RSFC. The potential influence of a specific low-frequency filtering range (0.04-0.15 Hz and 0.01-0.08 Hz) and three fNIRS parameters (oxy-Hb, deoxy-Hb, and total-Hb) on RSFC results were also examined.

Original languageEnglish (US)
Pages (from-to)242-249
Number of pages8
JournalJournal of Neuroscience Methods
Issue number2
StatePublished - Feb 15 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


  • Low-frequency fluctuation
  • Resting state functional connectivity
  • fNIRS


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