TY - JOUR
T1 - Use of PET to monitor the response of lung cancer to radiation treatment
AU - Erdi, Yusuf E.
AU - Macapinlac, Homer
AU - Rosenzweig, Kenneth E.
AU - Humm, John L.
AU - Larson, Steven M.
AU - Erdi, Alev K.
AU - Yorke, Ellen D.
N1 - Funding Information:
Acknowledgements. This work was supported by the Laurent and
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Approximately 170,000 people are diagnosed with lung cancer in the United States each year. Many of these patients receive external beam radiation for treatment. Fluorine-18 2-fluoro-2- deoxy-D-glucose positron emission tomography (FDG PET) is increasingly being used in evaluating non-small cell lung cancer and may be of clinical utility in assessing response to treatment. In this report, we present FDG PET images and data from two patients who were followed with a total of eight and seven serial FDG PET scans, respectively, through the entire course of their radiation therapy. Changes in several potential response parameters are shown versus time, including lesion volume (V(FDG)) by PET, SUV(av), SUV(max), and total lesion glycolysis (TLG) during the course of radiotherapy. The response parameters for patient 1 demonstrated a progressive decrease; however, the response parameters for patient 2 showed an initial decrease followed by an increase. The data presented here may suggest that the outcome of radiation therapy can be predicted by PET imaging, but this observation requires a study of additional patients.
AB - Approximately 170,000 people are diagnosed with lung cancer in the United States each year. Many of these patients receive external beam radiation for treatment. Fluorine-18 2-fluoro-2- deoxy-D-glucose positron emission tomography (FDG PET) is increasingly being used in evaluating non-small cell lung cancer and may be of clinical utility in assessing response to treatment. In this report, we present FDG PET images and data from two patients who were followed with a total of eight and seven serial FDG PET scans, respectively, through the entire course of their radiation therapy. Changes in several potential response parameters are shown versus time, including lesion volume (V(FDG)) by PET, SUV(av), SUV(max), and total lesion glycolysis (TLG) during the course of radiotherapy. The response parameters for patient 1 demonstrated a progressive decrease; however, the response parameters for patient 2 showed an initial decrease followed by an increase. The data presented here may suggest that the outcome of radiation therapy can be predicted by PET imaging, but this observation requires a study of additional patients.
KW - Lung cancer
KW - Positron emission tomography
KW - Radiation therapy
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U2 - 10.1007/s002590000258
DO - 10.1007/s002590000258
M3 - Article
C2 - 10952499
AN - SCOPUS:0033931766
SN - 0340-6997
VL - 27
SP - 861
EP - 866
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
IS - 7
ER -