Visual feedback discordance mediates changes in brain activity and effective connectivity: A stroke fMRI dynamic causal modeling study

Soha Saleh, Sergei V. Adamovich, Eugene Tunik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In this study we investigated the effect of visual feedback discordance in Virtual Reality (VR) on brain activity. Fifteen subjects with chronic stroke moved the less-Affected hand with concomitant feedback through a VR hand model corresponding to the ipsilateral (veridical) or contralateral side (mirrored). Visual feedback discordance (mirrored-feedback) was associated with an increase in ipsilesional (iM1) sensorimotor cortex activity (ipsilateral to movement). Effective connectivity analysis using dynamic causal modeling (DCM) revealed a facilitatory effect of mirrored-feedback on the interaction between bilateral posterior parietal cortices and iM1. These results indicate that mirrored-feedback training may enhance brain activity in the ipsilesional cortical motor system, likely driven by parietal areas. These neural changes may be important substrates for fostering neuroplasticity and behavioral benefits induced by mirror therapy.

Original languageEnglish (US)
Title of host publication2013 2nd International Conference on Advances in Biomedical Engineering, ICABME 2013
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages85-88
Number of pages4
ISBN (Electronic)9781479902514
DOIs
StatePublished - Oct 28 2013
Externally publishedYes
Event2013 2nd International Conference on Advances in Biomedical Engineering, ICABME 2013 - Tripoli, Lebanon
Duration: Sep 11 2013Sep 13 2013

Publication series

Name2013 2nd International Conference on Advances in Biomedical Engineering, ICABME 2013

Other

Other2013 2nd International Conference on Advances in Biomedical Engineering, ICABME 2013
CountryLebanon
CityTripoli
Period9/11/139/13/13

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Keywords

  • DCM
  • Motor Control
  • Stroke Rehabilitation
  • Virtual Reality
  • fMRI

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