@inproceedings{c56e2bba05fc4fcdb60d853f2880a165,
title = "Visual feedback discordance mediates changes in brain activity and effective connectivity: A stroke fMRI dynamic causal modeling study",
abstract = "In this study we investigated the effect of visual feedback discordance in Virtual Reality (VR) on brain activity. Fifteen subjects with chronic stroke moved the less-Affected hand with concomitant feedback through a VR hand model corresponding to the ipsilateral (veridical) or contralateral side (mirrored). Visual feedback discordance (mirrored-feedback) was associated with an increase in ipsilesional (iM1) sensorimotor cortex activity (ipsilateral to movement). Effective connectivity analysis using dynamic causal modeling (DCM) revealed a facilitatory effect of mirrored-feedback on the interaction between bilateral posterior parietal cortices and iM1. These results indicate that mirrored-feedback training may enhance brain activity in the ipsilesional cortical motor system, likely driven by parietal areas. These neural changes may be important substrates for fostering neuroplasticity and behavioral benefits induced by mirror therapy.",
keywords = "DCM, Motor Control, Stroke Rehabilitation, Virtual Reality, fMRI",
author = "Soha Saleh and Adamovich, {Sergei V.} and Eugene Tunik",
note = "Publisher Copyright: {\textcopyright} 2013 IEEE.; 2013 2nd International Conference on Advances in Biomedical Engineering, ICABME 2013 ; Conference date: 11-09-2013 Through 13-09-2013",
year = "2013",
month = oct,
day = "28",
doi = "10.1109/ICABME.2013.6648853",
language = "English (US)",
series = "2013 2nd International Conference on Advances in Biomedical Engineering, ICABME 2013",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "85--88",
booktitle = "2013 2nd International Conference on Advances in Biomedical Engineering, ICABME 2013",
address = "United States",
}