Abstract
Light-controlled sequential photolysis from a single nanoparticle is a challenge for controlled release. A wavelength-selective sequential photolysis from single gold nanoparticles is reported for the first time. In particular, it is also demonstrated that such nanoparticle can be used to sequentially release two payloads in living cells. In principle, this system can be extended to sequential release of multiple different types of payloads by rational design of diverse photocleavable linkers. It is expected that this work can provide a new tool for better orderly controlling cellular events that request high spatiotemporal manners.
Original language | English (US) |
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Article number | 2000321 |
Journal | Advanced Healthcare Materials |
Volume | 10 |
Issue number | 5 |
DOIs | |
State | Published - Mar 3 2021 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biomaterials
- Biomedical Engineering
- Pharmaceutical Science
Keywords
- chromophore
- controlled release
- gold nanoparticles
- photocleavable ligands
- stepwise photolysis