Wavelength-Selective Light-Controlled Stepwise Photolysis from Single Gold Nanoparticles

Yekui Zhou, Yuanwei Zhang, Wenhai Lin, Samuel J. Kesseli, Ling Huang, Yang Zhao, Xikuang Yao, Kai Huang, Gang Han

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Light-controlled sequential photolysis from a single nanoparticle is a challenge for controlled release. A wavelength-selective sequential photolysis from single gold nanoparticles is reported for the first time. In particular, it is also demonstrated that such nanoparticle can be used to sequentially release two payloads in living cells. In principle, this system can be extended to sequential release of multiple different types of payloads by rational design of diverse photocleavable linkers. It is expected that this work can provide a new tool for better orderly controlling cellular events that request high spatiotemporal manners.

Original languageEnglish (US)
Article number2000321
JournalAdvanced Healthcare Materials
Issue number5
StatePublished - Mar 3 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


  • chromophore
  • controlled release
  • gold nanoparticles
  • photocleavable ligands
  • stepwise photolysis


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